By acting on inflammation, hormones or even mediators of growth hormone, supplements can give results against acne.
Probiotics :
Studies on the intestine-brain axis are now numerous and we know that our intestinal microbiota influences, for example, our mental health. But what we know less is that there is also a link between our intestines and the health of our skin. This is what a new study in the journal Beneficial Microbes suggests. The researchers show that probiotic supplementation improves acne in adults and evoke the existence of an intestine-skin axis that could target the gastrointestinal tract with bacterial strains to improve the physiology of the skin.
"Acne is a chronic inflammatory disorder characterized by a number of different skin lesions. The pathogenesis of acne is complex and involves an increase in sebum production and hyperplasia of the sebaceous glands "explained the authors. "More and more data suggest that alterations in insulin signaling are implicated in the pathogenesis of acne in adults.""Insulin and IGF-1 (Insulin like Growth Factor) could exercise actions that promote acne. An increase in serum IGF-1 levels is associated with an increased risk of acne in women after adolescence.
On the other hand, the research carried out on the strain Lactobacillus rhamnosus SP1 (LSP1) shows that this probiotic normalizes the cutaneous expression of certain genes involved in the signaling of insulin.This small pilot study was conducted on 20 adult sufferers of acne. During a 12-week period, a first group of 10 people received supplementation with LSP1 probiotics. The other group received a placebo. Skin biopsies were performed at the beginning and end of treatment and researchers evaluated gene expression for IGF1 as well as FOXO1 transcription factor, a relative deficiency of which would play a key role in the pathogenesis of The acne. The clinical efficacy endpoint is the overall improvement rate on a 5-point scale.At the end of the study, the group taking probiotics showed a 32% decrease and a 65% increase in the expression of the genes coding respectively for the IGF1 growth factor and the FOXO1 factor."Our results show that 12 weeks of supplementation in LSP1 have allowed to normalize the dermal expression of the genes involved in the signaling of insulin in the areas of acne. This molecular change is accompanied by a significant improvement in the appearance of acne. This treatment is safe and well tolerated, "say the researchers.The exact mechanism by which probiotics normalize the expression of IGF1 and FOXO1 in the skin is not known but it is possible that probiotics improve insulin resistance through direct metabolic effects or by correcting An intestinal dysbiosis.
Soy isoflavones
The soy isoflavones are "phytoestrogens" (genistein and dadzein), which can behave like antiandrogens, in particular inhibiting an enzyme, 5-alpha-reductase, which transforms testosterone into dihydrotestosterone (DHT). In a double-blind, 12-week controlled study, researchers have shown that a soy extract with 160 mg of isoflavones has beneficial effects on acne, presumably by decreasing the level of DHT.
Green tea extracts
Green tea contains polyphenols called catechins, which are anti-inflammatory. A double-blind study tested the effects of a supplement of epigallocatechin gallate green tea (EGCG) on acne for 4 weeks (1500 mg decaffeinated extract) on 64 women aged 25 to 45 years. Compared with placebo, the supplement allowed a significant improvement in acne lesions.
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